The mannose receptor
نویسندگان
چکیده
منابع مشابه
Mannose receptor regulates motility
I f myoblasts are to fuse with nascent myotubes and thus form muscles, they must apparently migrate and chew up extracellular matrix (ECM), according to Jansen and Pavlath (page 403). These activities require expression of the mannose receptor (MR) in differentiating myoblasts. The pathway is induced when nascent myotubes secrete IL-4, which induced expression of the MR in myoblasts. Although M...
متن کاملLigand interactions of the cation-dependent mannose 6-phosphate receptor. Comparison with the cation-independent mannose 6-phosphate receptor.
The interactions of the bovine cation-dependent mannose 6-phosphate receptor with monovalent and divalent ligands have been studied by equilibrium dialysis. This receptor appears to be a homodimer or a tetramer. Each mole of receptor monomer bound 1.2 mol of the monovalent ligands, mannose 6-phosphate and pentamannose phosphate with Kd values of 8 X 10(-6) M and 6 X 10(-6) M, respectively and 0...
متن کاملStructural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor.
The mannose receptor family comprises four members in mammals, Endo180 (CD280), DEC-205 (CD205), phospholipase A(2) receptor (PLA(2)R) and the mannose receptor (MR, CD206), whose extracellular portion contains a similar domain arrangement: an N-terminal cysteine-rich domain (CysR) followed by a single fibronectin type II domain (FNII) and 8-10 C-type lectin-like domains (CTLDs). These proteins ...
متن کاملEnzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors.
Enzyme replacement therapy (ERT) is available for several lysosomal storage diseases. Except for Gaucher disease, for which an enzyme with exposed mannosyl residues targets mannose receptors (MR) on macrophages, ERT targets primarily the mannose 6-phosphate receptor (MPR). Most recombinant lysosomal enzymes contain oligosaccharides with both terminal mannosyl and mannose 6-phosphate residues. E...
متن کاملThe role of mannose sensitive and mannose resistant pili of Escherichia coli in urinary tract infection
In order to study the relationship between hrmolysin / ashesins of Escherichia coli and occurrence of urinary tract infection ( UTI), the capacity of 570 isolated E.coli in agglutination of human or guinea pig erythrocytes and their lysis were tested. These isolates were obtained from the urine of patients with bacteriuria and from the stool of healthy people. Three patterns of hemagglutinat...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2012
ISSN: 0741-5400
DOI: 10.1189/jlb.0512231